A systematic review uses repeatable analytical methods to collect secondary data and analyse it. It aims to identify, appraise and synthesise all the empirical evidence that meets pre-specified eligibility criteria to answer a specific research question.
Please note that searching for a systematic review requires highly advanced searching methods, and is more exhaustive than a literature review.
- Editorial: What Makes Systematic Reviews Systematic and Why Are They the Highest Level of Evidence. What makes the difference between a systematic review and a narrative literature review?
- Cochrane Handbook for Systematic Reviews of Interventions. The official guide that describes in detail the process of preparing and maintaining Cochrane systematic reviews on the effects of healthcare interventions. All authors should consult the handbook for guidance on the methods used in Cochrane systematic reviews.
- Centre for Reviews and Dissemination: Systematic Reviews: CRD’s Guidance for Undertaking Reviews in Health Care. CRD's guidance continues to be recommended as a source of good practice by agencies such as the National Institute for Health and Clinical Excellence (NICE). It's used widely both nationally and internationally.
- University of York: Systematic Reviews: A Practical Guide. Pages offering a brief introduction on how to conduct a systematic review
The review protocol sets out the methods to be used in the review and provides an explicit plan for your work. Decisions about the review question, inclusion criteria, search strategy, study selection, data extraction, quality assessment, data synthesis and plans for dissemination should be addressed.
- PRISMA: What is a Protocol?
- Centre for Reviews and Dissemination: Chapter 1.2 The Review Protocol
- PROSPERO: An international database of prospectively registered systematic reviews in health and social care: https://www.crd.york.ac.uk/PROSPERO/
- Centre for Reviews and Dissemination: Guidance for registering a systematic review protocol with PROSPERO
- Cochrane Handbook for Systematic Reviews of Interventions: Chapter 4: Searching for and selecting studies
- Centre for Reviews and Dissemination: Systematic Reviews: CRD’s Guidance for Undertaking Reviews in Health Care
- Levay, P. (2018) Systematic searching: practical ideas for improving results. Facet Publishing. Available here (Athens login required)
- Holly, C. et al. (2012) Comprehensive systematic review for advanced nursing practice. Springer Publishing. Available here (Athens login required)
Our Information Specialists offer tailor-made training sessions to support you with searching for systematic reviews. Please visit the following page to book a session: Training
If you'd like an Information Specialist embedded into your systematic review team, please email evidence@nca.nhs.uk. Leave your contact details and we'll be in touch to discuss your requirements and determine the level of support we're able to offer.
Table from: Grant MJ, Booth A. A typology of reviews: an analysis of 14 review types and associated methodologies. Health Info Libr J. 2009 Jun;26(2):91-108
Type |
Description |
Methods |
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Search |
Appraisal |
Synthesis |
Analysis |
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Critical review |
Aims to demonstrate writer has extensively researched literature and critically evaluated its quality. Goes beyond mere description to include degree of analysis and conceptual innovation. Typically results in hypothesis or model |
Seeks to identify most significant items in the field |
No formal quality assessment. Attempts to evaluate according to contribution |
Typically narrative, perhaps conceptual or chronological |
Significant component: seeks to identify conceptual contribution to embody existing or derive new theory |
Literature review |
Generic term: published materials that provide examination of recent or current literature. Can cover wide range of subjects at various levels of completeness and comprehensiveness. May include research findings |
May or may not include comprehensive searching |
May or may not include quality assessment |
Typically narrative |
Analysis may be chronological, conceptual, thematic, etc |
Mapping review/ Systematic map |
Map out and categorize existing literature from which to commission further reviews and/or primary research by identifying gaps in research literature |
Completeness of searching determined by time/scope constraints |
No formal quality assessment |
May be graphical and tabular |
Characterizes quantity and quality of literature, perhaps by study design and other key features. May identify need for primary or secondary research |
Meta-analysis |
Technique that statistically combines the results of quantitative studies to provide a more precise effect of the results |
Aims for exhaustive, comprehensive searching. May use funnel plot to assess completeness |
Quality assessment may determine inclusion/exclusion and/or sensitivity analyses |
Graphical and tabular with narrative commentary |
Numerical analysis of measures of effect assuming absence of heterogeneity |
Mixed studies review/mixed methods review |
Refers to any combination of methods where one significant component is a literature review (usually systematic). Within a review context it refers to a combination of review approaches for example combining quantitative with qualitative research or outcome with process studies |
Requires either very sensitive search to retrieve all studies or separately conceived quantitative and qualitative strategies |
Requires either a generic appraisal instrument or separate appraisal processes with corresponding checklists |
Typically both components will be presented as narrative and in tables. May also employ graphical means of integrating quantitative and qualitative studies |
Analysis may characterise both literatures and look for correlations between characteristics or use gap analysis to identify aspects absent in one literature but missing in the other |
Overview |
Generic term: summary of the [medical] literature that attempts to survey the literature and describe its characteristics |
May or may not include comprehensive searching (depends whether systematic overview or not) |
May or may not include quality assessment (depends whether systematic overview or not) |
Synthesis depends on whether systematic or not. Typically narrative but may include tabular features |
Analysis may be chronological, conceptual, thematic, etc. |
Qualitative systematic review/qualitative evidence synthesis |
Method for integrating or comparing the findings from qualitative studies. It looks for ‘themes’ or ‘constructs’ that lie in or across individual qualitative studies |
May employ selective or purposive sampling |
Quality assessment typically used to mediate messages not for inclusion/exclusion |
Qualitative, narrative synthesis |
Thematic analysis, may include conceptual models |
Rapid review |
Assessment of what is already known about a policy or practice issue, by using systematic review methods to search and critically appraise existing research |
Completeness of searching determined by time constraints |
Time-limited formal quality assessment |
Typically narrative and tabular |
Quantities of literature and overall quality/direction of effect of literature |
Scoping review |
Preliminary assessment of potential size and scope of available research literature. Aims to identify nature and extent of research evidence (usually including ongoing research) |
Completeness of searching determined by time/scope constraints. May include research in progress |
No formal quality assessment |
Typically tabular with some narrative commentary |
Characterizes quantity and quality of literature, perhaps by study design and other key features. Attempts to specify a viable review |
State-of-the-art review |
Tend to address more current matters in contrast to other combined retrospective and current approaches. May offer new perspectives on issue or point out area for further research |
Aims for comprehensive searching of current literature |
No formal quality assessment |
Typically narrative, may have tabular accompaniment |
Current state of knowledge and priorities for future investigation and research |
Systematic review |
Seeks to systematically search for, appraise and synthesis research evidence, often adhering to guidelines on the conduct of a review |
Aims for exhaustive, comprehensive searching |
Quality assessment may determine inclusion/exclusion |
Typically narrative with tabular accompaniment |
What is known; recommendations for practice. What remains unknown; uncertainty around findings, recommendations for future research |
Systematic search and review |
Combines strengths of critical review with a comprehensive search process. Typically addresses broad questions to produce ‘best evidence synthesis’ |
Aims for exhaustive, comprehensive searching |
May or may not include quality assessment |
Minimal narrative, tabular summary of studies |
What is known; recommendations for practice. Limitations |
Systematized review |
Attempt to include elements of systematic review process while stopping short of systematic review. Typically conducted as postgraduate student assignment |
May or may not include comprehensive searching |
May or may not include quality assessment |
Typically narrative with tabular accompaniment |
What is known; uncertainty around findings; limitations of methodology |
Umbrella review |
Specifically refers to review compiling evidence from multiple reviews into one accessible and usable document. Focuses on broad condition or problem for which there are competing interventions and highlights reviews that address these interventions and their results |
Identification of component reviews, but no search for primary studies |
Quality assessment of studies within component reviews and/or of reviews themselves |
Graphical and tabular with narrative commentary |
What is known; recommendations for practice. What remains unknown; recommendations for future research |